Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 3/20 | 0.50 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.49 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551588 | 0.87 | TMEM97 (0.48) | HTR1FACKR3TMEM97SIGMAR1PDPK1 | |
| SCHEMBL8552580 | 0.86 | HTR1F (0.65) | HTR1FMAPTTP53MCHR1POLB | |
| SCHEMBL8548442 | 0.80 | HTR1F (0.48) | HTR1FMAPTTP53SMN1; SMN2KCNK3 | |
| SCHEMBL8553330 | 0.79 | NPC1 (0.38) | HTR1FPDPK1CHEK2ABL1EGFR | |
| SCHEMBL8549366 | 0.78 | TP53 (0.41) | HTR1FMAPTTP53SMN1; SMN2CTNNB1 | |
| SCHEMBL8551441 | 0.77 | ACKR3 (0.49) | HTR1FACKR3TMEM97SIGMAR1PDPK1 | |
| Hydrochloric Acid SCHEMBL8548396 | 0.77 | SMN1; SMN2 (0.38) | HTR1FMAPTPOLBSMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL8551686 | 0.77 | TP53 (0.40) | HTR1FMAPTTP53SMN1; SMN2CTNNB1 | |
| SCHEMBL8551043 | 0.77 | HTR1F (0.42) | HTR1FMAPK1MAPTTP53POLB | |
| SCHEMBL8547488 | 0.77 | HTR1F (0.53) | HTR1FMAPTMCHR1POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |