Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1F | P30939 | 5/20 | 0.65 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547488 | 0.89 | HTR1F (0.53) | HTR1FMAPTSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8552089 | 0.89 | HTR1F (0.52) | HTR1FHTR1AHTR1DHTR1BHTR2A | |
| SCHEMBL8549636 | 0.87 | HTR1F (0.51) | HTR1FHTR1AHTR1DHTR1BMAPT | |
| SCHEMBL8549211 | 0.87 | HTR1F (0.49) | HTR1FMAPTRAB9AKDM4EALDH1A1 | |
| SCHEMBL8548549 | 0.86 | HTR1F (0.50) | HTR1FHTR1AMAPTTP53SMN1; SMN2 | |
| SCHEMBL8548442 | 0.86 | HTR1F (0.48) | HTR1FHTR1AMAPTTP53SMN1; SMN2 | |
| SCHEMBL8709033 | 0.85 | HTR1F (0.48) | HTR1FMAPTTP53MEN1KMT2A | |
| SCHEMBL8549838 | 0.83 | ALDH1A1 (0.47) | HTR1FHTR6MAPTTP53SMN1; SMN2 | |
| SCHEMBL8548445 | 0.82 | HTR1F (0.45) | HTR1FHTR1AMAPTTP53SMN1; SMN2 | |
| SCHEMBL8548295 | 0.80 | RAB9A (0.51) | MAPTTP53SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |