SCHEMBL8553330

SCHEMBL8553330

Cc1cc(F)ccc1C(=O)Nc1ccc2oc(C)c(CCN(C)Cc3ccsc3)c2c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
CTDSP1 Q9GZU7 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HTR1F P30939 4/20 0.38
KMT2A Q03164 2/20 0.37
MEN1 O00255 1/20 0.37
MAPT P10636 5/20 0.36
RXFP1 Q9HBX9 1/20 0.36
TP53 P04637 3/20 0.35
POLB P06746 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
PDK1 Q15118 2/20 0.34
BCHE P06276 1/20 0.34
MAOA P21397 1/20 0.34
ACHE P22303 1/20 0.34
MAOB P27338 1/20 0.34
HCRTR1 O43613 1/20 0.34
PPARG P37231 1/20 0.34
NCOR2 Q9Y618 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8548396 0.85 SMN1; SMN2 (0.38) NPC1RAB9ACTDSP1TDP1HTR1F
SCHEMBL8552089 0.84 HTR1F (0.52) NPC1RAB9ACTDSP1TDP1HTR1F
Hydrochloric Acid SCHEMBL8552477 0.84 NPC1 (0.39) NPC1RAB9ACTDSP1TDP1HTR1F
SCHEMBL8549366 0.83 TP53 (0.41) NPC1RAB9ACTDSP1TDP1HTR1F
Hydrochloric Acid SCHEMBL8551686 0.82 TP53 (0.40) NPC1RAB9ACTDSP1TDP1HTR1F
Hydrochloric Acid SCHEMBL8551526 0.80 MAPT (0.37) NPC1RAB9ACTDSP1TDP1HTR1F
SCHEMBL8548549 0.79 HTR1F (0.50) RAB9AHTR1FMAPTTP53POLB
SCHEMBL8549211 0.77 HTR1F (0.49) NPC1RAB9ACTDSP1TDP1HTR1F
SCHEMBL8709033 0.76 HTR1F (0.48) NPC1RAB9ACTDSP1TDP1HTR1F
SCHEMBL8552580 0.74 HTR1F (0.65) NPC1RAB9ATDP1HTR1FKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5792763-A MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS ELI LILLY AND COMPANY (US) 1998-08-11 US disclosed
WO-1998015545-A1 NEW SEROTONIN 5-HT1F AGONISTS ELI LILLY AND COMPANY (US) 1998-04-16 WO disclosed
EP-0835869-A2 New serotonin 5-HT1F agonists ELI LILLY AND COMPANY (US) 1998-04-15 EP disclosed