Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 4/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551491 | 0.92 | THRA (0.49) | THRATHRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8549251 | 0.89 | THRA (0.55) | THRATHRBCNR2HSD17B10SMN1; SMN2 | |
| SCHEMBL8548248 | 0.88 | THRA (0.49) | THRATHRBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8548540 | 0.86 | THRA (0.44) | THRATHRBSMN1; SMN2ALDH1A1ESR1 | |
| SCHEMBL8549323 | 0.82 | HSD17B10 (0.54) | HSD17B10SMN1; SMN2ALDH1A1POLBTSHR | |
| SCHEMBL27579122 | 0.77 | THRA (0.47) | THRATHRBCNR2HSD17B10ESR1 | |
| SCHEMBL13664228 | 0.76 | THRA (0.42) | THRATHRBSMN1; SMN2ESR1TSHR | |
| SCHEMBL13664126 | 0.74 | THRA (0.43) | THRATHRBCNR2SMN1; SMN2MEN1 | |
| SCHEMBL11929251 | 0.73 | THRA (0.49) | THRATHRBCNR2HSD17B10TSHR | |
| SCHEMBL10658494 | 0.73 | PTPN11 (0.46) | THRATHRBSMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |