Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.49 |
| ▸ | TPMT | P51580 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | FYN | P06241 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.36 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550905 | 0.90 | HSD17B10 (0.45) | HSD17B10GPR35TPMTHPGDALDH1A1 | |
| SCHEMBL8549612 | 0.88 | HSD17B10 (0.59) | HSD17B10GPR35TPMTLCKFYN | |
| SCHEMBL8551259 | 0.86 | HSD17B10 (0.41) | HSD17B10GPR35TPMTHPGDALDH1A1 | |
| SCHEMBL8546447 | 0.83 | HPGD (0.46) | HSD17B10HPGDALDH1A1MAPTLMNA | |
| SCHEMBL8548592 | 0.82 | THRA (0.50) | HSD17B10ALDH1A1MAPTTSHRPOLB | |
| SCHEMBL27851655 | 0.78 | HSD17B10 (0.62) | HSD17B10GPR35TPMTLCKFYN | |
| SCHEMBL6825228 | 0.78 | HSD17B10 (0.53) | HSD17B10GPR35TPMTLCKFYN | |
| SCHEMBL4113651 | 0.77 | CA2 (0.48) | HSD17B10TPMTHPGDALDH1A1PTPN1 | |
| SCHEMBL2970067 | 0.75 | HSD17B10 (0.70) | HSD17B10GPR35TPMTLCKFYN | |
| SCHEMBL4288497 | 0.74 | LCK (0.41) | HSD17B10LCKFYNHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |