Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.45 |
| ▸ | EDNRA | P25101 | 3/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 4/20 | 0.39 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551472 | 0.94 | EDNRB (0.43) | EDNRBEDNRAPLA2G2APDCD1CD274 | |
| SCHEMBL8547217 | 0.92 | EDNRB (0.46) | EDNRBEDNRAPLA2G2APDCD1CD274 | |
| SCHEMBL8549318 | 0.88 | EDNRB (0.43) | EDNRBEDNRAPDCD1CD274KDM4E | |
| SCHEMBL8551108 | 0.88 | EDNRB (0.50) | EDNRBEDNRAPLA2G2ADYRK1ATP53 | |
| SCHEMBL8549140 | 0.88 | EDNRB (0.48) | EDNRBEDNRAPLA2G2ADYRK1A | |
| SCHEMBL8547859 | 0.86 | EDNRB (0.44) | EDNRBEDNRAPLA2G2APDCD1CD274 | |
| SCHEMBL8547935 | 0.86 | EDNRB (0.43) | EDNRBEDNRAPLA2G2ATP53GAA | |
| SCHEMBL8547214 | 0.86 | EDNRB (0.56) | EDNRBEDNRATP53GAAPOLB | |
| SCHEMBL8547424 | 0.85 | EDNRB (0.61) | EDNRBEDNRAPLA2G2AGAAKDM4E | |
| SCHEMBL8547930 | 0.84 | EDNRB (0.47) | EDNRBEDNRAGAAKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |