Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 7/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 3/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 2/20 | 0.38 |
| ▸ | PYGL | P06737 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550541 | 0.89 | DRD2 (0.52) | CCR2DRD2SLC6A4EPHX2EPHX1 | |
| SCHEMBL8552203 | 0.88 | CCR2 (0.43) | CCR2DRD2SLC6A4EPHX2RAB9A | |
| SCHEMBL8553059 | 0.87 | DRD2 (0.42) | DRD2SLC6A4EPHX2RAB9AMAPT | |
| SCHEMBL7487120 | 0.84 | CCR2 (0.61) | CCR2DRD2 | |
| SCHEMBL8702974 | 0.83 | DRD2 (0.53) | CCR2DRD2SLC6A4CCR3RAB9A | |
| SCHEMBL8546639 | 0.82 | SMN1; SMN2 (0.48) | CCR2DRD2SLC6A4EPHX2EPHX1 | |
| SCHEMBL8551299 | 0.80 | DRD2 (0.52) | CCR2DRD2SLC6A4CCR3EPHX1 | |
| SCHEMBL8703019 | 0.80 | DRD2 (0.53) | CCR2DRD2SLC6A4CCR3RAB9A | |
| SCHEMBL8552297 | 0.80 | DRD2 (0.48) | DRD2SLC6A4 | |
| SCHEMBL8550206 | 0.80 | DRD2 (0.47) | DRD2SLC6A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |