Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 5/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 9/20 | 0.37 |
| ▸ | HTR1B | P28222 | 7/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553525 | 0.88 | DRD2 (0.43) | DRD2SLC6A4BCHENPC1RAB9A | |
| SCHEMBL8548757 | 0.87 | CCR2 (0.46) | DRD2SLC6A4RAB9AMAPTEPHX2 | |
| SCHEMBL7481757 | 0.84 | HTR1D (0.55) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8552297 | 0.80 | DRD2 (0.48) | DRD2SLC6A4 | |
| SCHEMBL8550766 | 0.80 | HTR1D (0.50) | DRD2RAB9ASMN1; SMN2HPGDMAPT | |
| SCHEMBL8702974 | 0.80 | DRD2 (0.53) | DRD2SLC6A4BCHENPC1RAB9A | |
| SCHEMBL8546639 | 0.79 | SMN1; SMN2 (0.48) | DRD2SLC6A4SMN1; SMN2KMT2AHTR1D | |
| SCHEMBL8552288 | 0.78 | DRD2 (0.43) | DRD2SLC6A4 | |
| SCHEMBL8552203 | 0.78 | CCR2 (0.43) | DRD2SLC6A4RAB9AMAPTHTR1D | |
| SCHEMBL8707969 | 0.77 | DRD2 (0.42) | DRD2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |