SCHEMBL8549023

SCHEMBL8549023

CCCNCCc1c[nH]c2ccc(OC)c(Cl)c12

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MPO P05164 3/20 0.48
HTR1D P28221 1/20 0.46
MTNR1A P48039 2/20 0.46
MTNR1B P49286 2/20 0.46
NQO2 P16083 1/20 0.46
HTR1A P08908 5/20 0.45
HTR2A P28223 6/20 0.44
HTR6 P50406 5/20 0.43
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
DRD2 P14416 1/20 0.41
HTR7 P34969 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fumaric Acid SCHEMBL8545087 0.90 MTNR1A (0.46) MPOHTR1DMTNR1AMTNR1BNQO2
Fumaric Acid SCHEMBL8545085 0.90 MTNR1A (0.46) MPOHTR1DMTNR1AMTNR1BNQO2
SCHEMBL8544722 0.87 HTR2A (0.53) MPOHTR1DMTNR1AMTNR1BNQO2
SCHEMBL8544580 0.84 MTNR1A (0.47) MTNR1AMTNR1BNQO2HTR1AHTR2A
SCHEMBL8545111 0.83 MTNR1A (0.53) MPOMTNR1AMTNR1BNQO2HTR1A
SCHEMBL31244443 0.82 MTNR1A (0.65) MPOMTNR1AMTNR1BHTR1AHTR2A
SCHEMBL8545108 0.81 MTNR1A (0.55) MTNR1AMTNR1BNQO2SLC6A4
SCHEMBL2541508 0.80 HTR2A (0.65) HTR1DHTR1AHTR2AHTR6HTR7
SCHEMBL8543450 0.77 HTR1A (0.71) MPOHTR1DMTNR1AMTNR1BHTR1A
SCHEMBL8543561 0.77 HTR2A (0.46) MPOHTR1DMTNR1AMTNR1BNQO2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP claimed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US claimed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP claimed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO claimed