SCHEMBL8544722

SCHEMBL8544722

CNCCc1c[nH]c2ccc(OC)c(Cl)c12

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 4/20 0.53
MTNR1A P48039 4/20 0.49
MTNR1B P49286 4/20 0.49
NQO2 P16083 1/20 0.49
HTR1A P08908 4/20 0.48
KDM4E B2RXH2 3/20 0.47
ALDH1A1 P00352 2/20 0.47
HTT P42858 1/20 0.47
MEN1 O00255 2/20 0.46
CYP2D6 P10635 2/20 0.46
KMT2A Q03164 2/20 0.46
HTR2C P28335 1/20 0.46
MPO P05164 1/20 0.46
HTR6 P50406 2/20 0.44
HTR1D P28221 1/20 0.44
HTR1B P28222 1/20 0.44
CHRNB2 P17787 1/20 0.43
CHRNA7 P36544 1/20 0.43
CHRNA4 P43681 1/20 0.43
POLB P06746 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8549023 0.87 MPO (0.48) HTR2AMTNR1AMTNR1BNQO2HTR1A
SCHEMBL8544580 0.85 MTNR1A (0.47) HTR2AMTNR1AMTNR1BNQO2HTR1A
SCHEMBL2541508 0.84 HTR2A (0.65) HTR2AHTR1AMEN1KMT2AHTR2C
SCHEMBL8543561 0.84 HTR2A (0.46) HTR2AMTNR1AMTNR1BNQO2HTR1A
SCHEMBL8545111 0.82 MTNR1A (0.53) HTR2AMTNR1AMTNR1BNQO2HTR1A
SCHEMBL8545108 0.82 MTNR1A (0.55) MTNR1AMTNR1BNQO2MEN1CYP2D6
SCHEMBL8543450 0.82 HTR1A (0.71) HTR2AMTNR1AMTNR1BHTR1ACYP2D6
SCHEMBL23069128 0.79 MTNR1A (0.71) HTR2AMTNR1AMTNR1BHTR1AKDM4E
SCHEMBL29968548 0.79 MTNR1A (0.71) HTR2AMTNR1AMTNR1BHTR1AKDM4E
SCHEMBL8546408 0.78 HTR1A (0.52) HTR2AMTNR1AMTNR1BHTR1AKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP claimed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP claimed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO claimed
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed