SCHEMBL8545111

SCHEMBL8545111

COc1ccc2[nH]cc(CCNCC(C)=O)c2c1Cl

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 11/20 0.53
MTNR1B P49286 11/20 0.53
NQO2 P16083 2/20 0.53
MEN1 O00255 4/20 0.45
KMT2A Q03164 4/20 0.45
CYP1A2 P05177 3/20 0.45
CYP3A4 P08684 3/20 0.45
CYP2D6 P10635 3/20 0.45
HTR2B P41595 3/20 0.45
LMNA P02545 1/20 0.45
CYP2C9 P11712 1/20 0.45
NFKB1 P19838 1/20 0.45
MAPK1 P28482 1/20 0.45
SLC6A4 P31645 1/20 0.45
CYP2C19 P33261 1/20 0.45
THPO P40225 1/20 0.45
HIF1A Q16665 1/20 0.45
ABCG2 Q9UNQ0 1/20 0.42
OPRM1 P35372 1/20 0.41
OPRD1 P41143 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8549023 0.83 MPO (0.48) MTNR1AMTNR1BNQO2SLC6A4HTR1A
SCHEMBL8544722 0.82 HTR2A (0.53) MTNR1AMTNR1BNQO2MEN1KMT2A
SCHEMBL8544580 0.82 MTNR1A (0.47) MTNR1AMTNR1BNQO2MEN1KMT2A
Fumaric Acid SCHEMBL8545087 0.81 MTNR1A (0.46) MTNR1AMTNR1BNQO2MEN1KMT2A
Fumaric Acid SCHEMBL8545085 0.81 MTNR1A (0.46) MTNR1AMTNR1BNQO2MEN1KMT2A
SCHEMBL8545108 0.81 MTNR1A (0.55) MTNR1AMTNR1BNQO2MEN1KMT2A
Oxalic Acid SCHEMBL8549166 0.77 HTR2A (0.56) MTNR1AMTNR1BNQO2MEN1KMT2A
SCHEMBL2541508 0.76 HTR2A (0.65) MEN1KMT2ACYP1A2HTR2BNFKB1
SCHEMBL8549303 0.75 MTNR1A (0.41) MTNR1AMTNR1BNQO2HTR2BHTR1A
Fumaric Acid SCHEMBL8549920 0.74 HTR2A (0.53) MTNR1AMTNR1BNQO2MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0593513-B1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1998-10-28 EP disclosed
US-5571833-A TREATMENT OF MIGRAINE, PORTAL HYPERTENSION SMITHKLINE BEECHAM PLC (GB) 1996-11-05 US disclosed
EP-0593513-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES SMITHKLINE BEECHAM PLC (GB) 1994-04-27 EP disclosed
WO-1993000333-A1 TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE OR 5-HT2 RECEPTOR AGONISTS SMITHKLINE BEECHAM PLC (GB) 1993-01-07 WO disclosed