Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL261957 | 0.82 | MAPT (0.49) | MAPTRAB9ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL8552944 | 0.80 | RAB9A (0.54) | MAPTRAB9ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL846695 | 0.78 | TRPV1 (0.58) | MAPTRAB9ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL6964824 | 0.75 | ALDH1A1 (0.51) | MAPTRAB9ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL6956521 | 0.74 | MAPT (0.42) | MAPTRAB9ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL6966945 | 0.74 | MAPT (0.57) | MAPTRAB9ANPC1ALDH1A1GAA | |
| SCHEMBL22641580 | 0.73 | TLR8 (0.46) | MAPTRAB9ASMN1; SMN2KMT2ANPC1 | |
| SCHEMBL21311190 | 0.72 | KMT2A (0.60) | MAPTKMT2AALDH1A1GAAMAPK1 | |
| SCHEMBL3772211 | 0.71 | NPC1 (0.67) | MAPTRAB9AKMT2ANPC1ALDH1A1 | |
| SCHEMBL180365 | 0.70 | TLR8 (0.65) | MAPTRAB9ASMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850222-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | Samjin Pharmaceutical Co., Ltd. (KR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1998000402-A1 | PIPERAZINE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF | SAMJIN PHARMACEUTICAL CO., LTD. (KR) | 1998-01-08 | — | — | WO | disclosed |