Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 3/20 | 0.52 |
| ▸ | RXRB | P28702 | 2/20 | 0.52 |
| ▸ | RXRG | P48443 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 3/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.38 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8146420 | 0.82 | NR4A2 (0.55) | RXRARXRBRXRGNPC1ALDH1A1 | |
| SCHEMBL8151850 | 0.81 | RXRA (0.51) | RXRARXRBRXRGNPC1ALDH1A1 | |
| SCHEMBL8140604 | 0.81 | RXRA (0.51) | RXRARXRBRXRGNPC1ALDH1A1 | |
| SCHEMBL31194854 | 0.80 | MAPK13 (0.61) | RXRARXRBRXRGNPC1ALDH1A1 | |
| SCHEMBL8154083 | 0.79 | PTGS2 (0.42) | — | |
| SCHEMBL8560253 | 0.77 | F10 (0.37) | ELANENR4A2 | |
| SCHEMBL8148454 | 0.75 | RXRA (0.51) | RXRARXRBRXRGELANENR4A2 | |
| SCHEMBL8148481 | 0.74 | NOX1 (0.45) | RXRARXRBRXRGALDH1A1NR4A2 | |
| SCHEMBL7504769 | 0.72 | PTGS2 (0.67) | — | |
| SCHEMBL7502654 | 0.72 | PTGS2 (0.67) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |