Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | PRKCI | P41743 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550246 | 0.79 | HTR2B (0.48) | MAPTHTR2BKDM4EMEN1TP53 | |
| SCHEMBL8789947 | 0.79 | KMT2A (0.51) | MAPTHTR2BKDM4EMEN1TP53 | |
| SCHEMBL8544057 | 0.71 | EGFR (0.48) | EGFRPRKCQPRKCDMAPK14 | |
| SCHEMBL16068103 | 0.70 | GAA (0.58) | MAPTKDM4ETP53TDP1 | |
| SCHEMBL8543006 | 0.70 | FGFR2 (0.55) | EGFRPRKCIJAK2PRKCQPRKCD | |
| SCHEMBL8543878 | 0.70 | MAPKAPK2 (0.56) | MAPTKDM4EMEN1KMT2ATDP1 | |
| SCHEMBL31735804 | 0.69 | BRD4 (0.45) | MAPTHTR2BKDM4EMEN1TP53 | |
| SCHEMBL8944979 | 0.69 | HTR2B (0.74) | MAPTHTR2BKDM4EMEN1TP53 | |
| SCHEMBL31735577 | 0.68 | BPTF (0.60) | MAPTHTR2BKDM4EMEN1TP53 | |
| SCHEMBL31035921 | 0.68 | PRKCI (0.55) | MAPTHTR2BKDM4EMEN1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4970219-A | TOPICAL ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-13 | — | — | US | claimed |
| EP-0405425-B1 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-08-12 | — | — | EP | disclosed |
| US-5405856-A | Skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5221682-A | Skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-06-22 | — | — | US | disclosed |
| US-5034403-A | Topical antiinflammatory agents for skin disorders | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-07-23 | — | — | US | disclosed |
| US-4983615-A | ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-01-08 | — | — | US | disclosed |
| EP-0405425-A2 | Heteroarylamino- and heteroaryloxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4970219-A | TOPICAL ANTIINFLAMMATORY AGENTS | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-11-13 | — | — | US | disclosed |