Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.48 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 5/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.41 |
| ▸ | DRD1 | P21728 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8757616 | 0.79 | HTR2A (0.55) | ALDH1A1HTR6HTR2A | |
| SCHEMBL8757614 | 0.78 | HTR2A (0.54) | HTR6HTR2A | |
| SCHEMBL9501537 | 0.78 | HTR2A (0.54) | HTR2A | |
| SCHEMBL5185937 | 0.77 | MAPT (0.60) | ALDH1A1HTTHTR6HTR1AHTR2A | |
| SCHEMBL8618152 | 0.77 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BHTR6HTR1A | |
| SCHEMBL8546269 | 0.77 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BALDH1A1HTT | |
| SCHEMBL8758865 | 0.73 | ALDH1A1 (0.62) | ALDH1A1HTTNCOA1NCOA3HTR6 | |
| SCHEMBL5186059 | 0.72 | CYP2D6 (0.59) | HTR6HTR1AHTR2AHTR7LMNA | |
| SCHEMBL5185949 | 0.71 | LMNA (0.55) | HTR6HTR1AHTR2AHTR7LMNA | |
| SCHEMBL5187801 | 0.70 | KCNH2 (0.56) | HTR6HTR1AHTR2AHTR7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677042-B1 | SELECTIVE LIGANDS OF 5HT1D-5HT1B RECEPTORS DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS | PF MEDICAMENT (FR) | 1998-07-22 | — | — | EP | claimed |
| EP-0677042-B1 | SELECTIVE LIGANDS OF 5HT1D-5HT1B RECEPTORS DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS | PF MEDICAMENT (FR) | 1998-07-22 | — | — | EP | disclosed |