Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 6/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | HTR1A | P08908 | 7/20 | 0.46 |
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | DRD1 | P21728 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 2/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 6/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546269 | 0.86 | ADRA1D (0.49) | ADRA1DADRA1AHTR1AHTR2AADRA1B | |
| SCHEMBL8757616 | 0.81 | HTR2A (0.55) | HTR2ACNR1HTR6 | |
| SCHEMBL240727 | 0.81 | HTR1A (0.55) | ADRA1DADRA1AHTR1AHTR2AADRA1B | |
| SCHEMBL8757614 | 0.80 | HTR2A (0.54) | HTR2ACNR1HTR6 | |
| SCHEMBL9501537 | 0.80 | HTR2A (0.54) | HTR2ACNR1 | |
| SCHEMBL8549631 | 0.77 | ADRA1D (0.49) | ADRA1DADRA1AHTR1AHTR2AADRA1B | |
| SCHEMBL5187310 | 0.76 | HTR1A (0.60) | ADRA1DADRA1AHTR1AHTR2AADRA1B | |
| SCHEMBL5366461 | 0.75 | HTR1A (0.62) | HTR1AHTR2ADRD2HTR2CHTR7 | |
| SCHEMBL5187168 | 0.74 | HTR1A (0.62) | HTR1AHTR2ADRD2HTR2CHTR7 | |
| SCHEMBL28374901 | 0.73 | HTR7 (0.56) | HTR1AHTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0677042-B1 | SELECTIVE LIGANDS OF 5HT1D-5HT1B RECEPTORS DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS | PF MEDICAMENT (FR) | 1998-07-22 | — | — | EP | claimed |
| EP-0677042-B1 | SELECTIVE LIGANDS OF 5HT1D-5HT1B RECEPTORS DERIVED FROM INDOLE-PIPERAZINE USEFUL AS MEDICAMENTS | PF MEDICAMENT (FR) | 1998-07-22 | — | — | EP | disclosed |