Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | PIR | O00625 | 1/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22980539 | 0.81 | CA12 (0.45) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL21818960 | 0.80 | ALDH1A1 (0.59) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL30041840 | 0.80 | TSHR (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL7867810 | 0.80 | TSHR (0.47) | MEN1KMT2ASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL8548777 | 0.78 | HTR1D (0.54) | DRD2HTR1D | |
| SCHEMBL30147511 | 0.78 | ALDH1A1 (0.61) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL29649399 | 0.78 | KMT2A (0.63) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL7092149 | 0.78 | DRD2 (0.40) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL20861044 | 0.76 | TAS1R3 (0.63) | SMN1; SMN2HDAC6HDAC8HDAC2NPC1 | |
| SCHEMBL21883070 | 0.76 | ALDH1A1 (0.50) | MEN1KMT2AHPGDSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | claimed |
| EP-0836599-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-22 | — | — | EP | disclosed |
| WO-1997002259-A1 | 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES | PHARMACIA & UPJOHN COMPANY (US) | 1997-01-23 | — | — | WO | disclosed |