Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29814297 | 1.00 | GPR35 (0.43) | GPR35MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL10580640 | 0.81 | ALDH1A1 (0.41) | GPR35MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL7484667 | 0.80 | ALDH1A1 (0.42) | GPR35MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL15427979 | 0.80 | ALDH1A1 (0.48) | GPR35MEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL1979879 | 0.80 | PARP1 (0.41) | GPR35MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL8550301 | 0.80 | GPR35 (0.41) | GPR35MEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL8117804 | 0.80 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1KDM4EMAPT | |
| SCHEMBL7084146 | 0.80 | MEN1 (0.46) | MEN1KMT2AALDH1A1HPGDHTT | |
| SCHEMBL727921 | 0.80 | PARP1 (0.44) | MEN1KMT2AALDH1A1MAPK1MAPT | |
| SCHEMBL29814344 | 0.78 | PARP1 (0.43) | MEN1KMT2AALDH1A1HPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112010864-B | Vascular endothelial growth factor receptor inhibitor and preparation method and application thereof | 江苏威凯尔医药科技有限公司 | 2022-08-26 | — | — | CN | disclosed |
| CN-110577546-B | VEGFR inhibitor and preparation method and application thereof | 江苏威凯尔医药科技有限公司 | 2021-09-07 | — | — | CN | disclosed |
| CN-112010864-A | Vascular endothelial growth factor receptor inhibitor and preparation method and application thereof | 江苏威凯尔医药科技有限公司 | 2020-12-01 | — | — | CN | disclosed |
| CN-110577546-A | VEGFR inhibitor and preparation method and application thereof | 江苏威凯尔医药科技有限公司 | 2019-12-17 | — | — | CN | disclosed |
| EP-0736025-B1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-22 | — | — | EP | disclosed |
| US-5700818-A | Dihydrobenzofuranyl-biphenyl carboxamides having 5HT1D antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0736025-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT 1D? ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017401-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |