Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10580640 | 0.81 | ALDH1A1 (0.41) | GPR35MAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL29814297 | 0.80 | GPR35 (0.43) | GPR35MAPTALDH1A1CYP3A4GAA | |
| SCHEMBL7484667 | 0.80 | ALDH1A1 (0.42) | GPR35MAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL7084146 | 0.80 | MEN1 (0.46) | ALDH1A1CYP3A4TSHRMEN1KMT2A | |
| SCHEMBL1979879 | 0.80 | PARP1 (0.41) | GPR35MAPTALDH1A1CYP3A4TSHR | |
| SCHEMBL15427979 | 0.80 | ALDH1A1 (0.48) | GPR35MAPTALDH1A1CYP3A4GAA | |
| SCHEMBL8550097 | 0.80 | GPR35 (0.43) | GPR35MAPTALDH1A1CYP3A4GAA | |
| SCHEMBL8117804 | 0.80 | ALDH1A1 (0.42) | MAPTALDH1A1CYP3A4GAATSHR | |
| SCHEMBL727921 | 0.76 | PARP1 (0.44) | MAPTALDH1A1CYP3A4MEN1KMT2A | |
| SCHEMBL31239506 | 0.76 | HTR1A (0.40) | MEN1KMT2ARAB9APARP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0736025-B1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-07-22 | — | — | EP | disclosed |
| US-5700818-A | Dihydrobenzofuranyl-biphenyl carboxamides having 5HT1D antagonistic activity | SMITHKLINE BEECHAM P.L.C. (GB) | 1997-12-23 | — | — | US | disclosed |
| EP-0736025-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT 1D? ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1996-10-09 | — | — | EP | disclosed |
| WO-1995017401-A1 | DYHYDROBENZOFURANYL-BIPHENYL CARBOXAMIDES HAVING 5HT1D ANTAGONISTIC ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1995-06-29 | — | — | WO | disclosed |