Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.55 |
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | DRD4 | P21917 | 3/20 | 0.55 |
| ▸ | GRM5 | P41594 | 3/20 | 0.55 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.53 |
| ▸ | HTR2B | P41595 | 1/20 | 0.53 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.53 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.50 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.49 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547905 | 0.88 | ADAM17 (0.53) | DRD3DRD2DRD4SIGMAR1HTR2A | |
| SCHEMBL4502402 | 0.85 | GRM5 (0.62) | DRD3DRD2DRD4GRM5DRD1 | |
| SCHEMBL29438690 | 0.85 | GRM5 (0.62) | DRD3DRD2DRD4GRM5DRD1 | |
| SCHEMBL8545172 | 0.85 | AOC3 (0.54) | GRM5 | |
| SCHEMBL8549552 | 0.85 | AOC3 (0.54) | GRM5 | |
| SCHEMBL8549557 | 0.85 | GRM5 (0.49) | GRM5 | |
| SCHEMBL8548927 | 0.84 | ITGB3 (0.53) | GRM5 | |
| SCHEMBL380250 | 0.83 | DRD3 (0.53) | DRD3DRD2DRD4GRM5DRD1 | |
| SCHEMBL3693926 | 0.83 | DRD3 (0.56) | DRD3DRD2DRD4GRM5DRD1 | |
| SCHEMBL8547139 | 0.83 | MAOA (0.53) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526402-B1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA GEIGY AG (CH) | 1998-01-21 | — | — | EP | disclosed |
| US-5350761-A | Lipoxygenase inhibitors as antiinflammatory agents and antiallergens | CIBA-GEIGY CORPORATION (US) | 1994-09-27 | — | — | US | disclosed |
| US-5334600-A | Lipoxygenase inhibitors | CIBA-GEIGY CORPORATION (US) | 1994-08-02 | — | — | US | disclosed |
| US-5260316-A | Lipoxygenase inhibitor | CIBA-GEIGY CORPORATION (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0526402-A1 | Heteroaryl substituted hydroxylamine derivatives as lipoxygenase inhibitors | CIBA-GEIGY AG (CH) | 1993-02-03 | — | — | EP | disclosed |