Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | CFD | P00746 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
| ▸ | PPIB | P23284 | 1/20 | 0.46 |
| ▸ | PPID | Q08752 | 1/20 | 0.46 |
| ▸ | PPIG | Q13427 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27537790 | 0.94 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2EPHX1CFD | |
| SCHEMBL8547013 | 0.88 | HPGD (0.57) | NPC1RAB9ASMN1; SMN2EPHX1GAA | |
| SCHEMBL8549654 | 0.84 | CARM1 (0.51) | NPC1RAB9ASMN1; SMN2PTPN1ALDH1A1 | |
| SCHEMBL8546557 | 0.83 | LMNA (0.53) | NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL8546499 | 0.82 | HPGD (0.51) | SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL1990363 | 0.81 | NPC1 (0.69) | NPC1RAB9AALDH1A1EPHX2 | |
| SCHEMBL690027 | 0.80 | NPC1 (0.59) | NPC1RAB9AALDH1A1EPHX2CYP1A2 | |
| SCHEMBL8549624 | 0.80 | HPGD (0.49) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8550343 | 0.80 | HSD17B10 (0.46) | EPHX1ALDH1A1EPHX2TSHR | |
| SCHEMBL8549404 | 0.79 | HTR2C (0.49) | NPC1RAB9AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696585-B1 | NOVEL BISOXADIAZOLIDINE DERIVATIVE | YAMANOUCHI PHARMA CO LTD (JP) | 1998-12-16 | — | — | EP | disclosed |
| US-5643931-A | ANTIDIABETIC AGENTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-07-01 | — | — | US | disclosed |
| EP-0696585-A1 | NOVEL BISOXADIAZOLIDINE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1996-02-14 | — | — | EP | disclosed |