Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 5/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CTSL | P07711 | 2/20 | 0.37 |
| ▸ | CTSB | P07858 | 2/20 | 0.37 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552888 | 0.89 | NPC1 (0.40) | NPC1LMNATP53RAB9AKMT2A | |
| SCHEMBL8554124 | 0.85 | NPC1 (0.39) | NPC1LMNATP53RAB9AKMT2A | |
| SCHEMBL8553246 | 0.75 | NTRK1 (0.39) | LMNASMN1; SMN2NTRK1ALDH1A1 | |
| SCHEMBL8555328 | 0.73 | GAA (0.69) | NPC1LMNARAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL8553146 | 0.69 | NTRK1 (0.54) | NPC1LMNATP53RAB9ASMN1; SMN2 | |
| SCHEMBL17129871 | 0.69 | CTSS (0.43) | NPC1LMNATP53RAB9AKMT2A | |
| SCHEMBL17129866 | 0.69 | NTRK1 (0.44) | CTSSNTRK1CTSLCTSBCTSK | |
| SCHEMBL6968295 | 0.67 | BRD9 (0.40) | NPC1LMNATP53RAB9AKMT2A | |
| SCHEMBL17129880 | 0.67 | NTRK1 (0.42) | NPC1LMNATP53RAB9AKMT2A | |
| SCHEMBL8553171 | 0.66 | NTRK1 (0.41) | GAANTRK1KDM4EJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885890-A1 | SULFONYLUREIDOPYRAZOLE DERIVATIVES | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |