Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.42 |
| ▸ | EDNRA | P25101 | 2/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549574 | 0.98 | EDNRB (0.43) | EDNRBEDNRAPDE4BPDE4DPDE4A | |
| SCHEMBL8547930 | 0.91 | EDNRB (0.47) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8547864 | 0.88 | EDNRB (0.49) | EDNRBEDNRAPTPN1 | |
| SCHEMBL8547478 | 0.87 | EDNRB (0.43) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8549318 | 0.86 | EDNRB (0.43) | EDNRBEDNRAKDM4EHTTPTPN1 | |
| SCHEMBL8547163 | 0.86 | EDNRB (0.45) | EDNRBEDNRAKDM4EGAAHSD17B10 | |
| SCHEMBL8547597 | 0.84 | EDNRB (0.47) | EDNRBEDNRAPDE4BPDE4DPDE4A | |
| SCHEMBL8549234 | 0.84 | EDNRB (0.52) | EDNRBEDNRAPTGDR2KDM4EGAA | |
| SCHEMBL8548187 | 0.83 | EDNRB (0.46) | EDNRBEDNRAGAAMEN1KMT2A | |
| SCHEMBL8548858 | 0.83 | EDNRB (0.45) | EDNRBEDNRAKDM4EHTTPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |