Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA4 | P22748 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | USP7 | Q93009 | 2/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544682 | 0.79 | ACHE (0.49) | DRD4CA2CA4CA9USP7 | |
| SCHEMBL2143728 | 0.74 | DRD4 (0.41) | DRD4CA2CA4CA9USP7 | |
| SCHEMBL557654 | 0.67 | KDM1A (0.53) | KMT2AKDM4EMEN1HTTACHE | |
| SCHEMBL8542085 | 0.63 | ACHE (0.50) | DRD4KMT2AKDM4EMEN1BCHE | |
| SCHEMBL4520161 | 0.63 | CCNT1 (0.46) | DRD4CA2CA4CA9USP7 | |
| SCHEMBL4510261 | 0.61 | NPC1 (0.42) | DRD4CA2CA4CA9CA1 | |
| SCHEMBL2143831 | 0.61 | PIK3CG (0.46) | DRD4CA2CA4CA9KMT2A | |
| SCHEMBL5558005 | 0.61 | CA2 (0.41) | DRD4CA2CA4CA9USP7 | |
| SCHEMBL8550680 | 0.60 | CDK4 (0.32) | — | |
| SCHEMBL11942158 | 0.60 | ALOX5 (0.41) | DRD4CA2CA4CA9HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560231-B1 | Pyrazolo(3,4-a)acridine derivatives as analgesics | HOECHST MARION ROUSSEL INC (US) | 1998-06-03 | — | — | EP | disclosed |
| EP-0560231-A1 | Pyrazolo(3,4-a)acridine derivatives as analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-09-15 | — | — | EP | disclosed |
| US-5179100-A | Analgesics | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-01-12 | — | — | US | disclosed |