Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.39 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.39 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552171 | 0.83 | MAP2K1 (0.40) | ALDH1A1KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL7437541 | 0.80 | KDM4E (0.50) | ALDH1A1KDM4EMAPTHPGDLMNA | |
| SCHEMBL8550700 | 0.78 | KDM4E (0.49) | ALDH1A1KDM4EL3MBTL1MAPTTDP1 | |
| SCHEMBL30443795 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL29024296 | 0.77 | ALDH1A1 (0.46) | ALDH1A1KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL8417432 | 0.74 | ALDH1A1 (0.41) | ALDH1A1KDM4EL3MBTL1MAPTTDP1 | |
| SCHEMBL4370965 | 0.71 | GRIA2 (0.49) | ALDH1A1KDM4EL3MBTL1MAPTMEN1 | |
| SCHEMBL2604 | 0.70 | NLRP3 (0.41) | ALDH1A1KDM4EL3MBTL1MAPTTDP1 | |
| SCHEMBL2104 | 0.70 | NLRP3 (0.43) | ALDH1A1KDM4EL3MBTL1MAPTGRIA2 | |
| SCHEMBL7436474 | 0.69 | AXL (0.41) | ALDH1A1HPGDLMNAGRIA2GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |