Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.39 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | OXTR | P30559 | 2/20 | 0.37 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2730 | 0.80 | LTB4R2 (0.53) | OXTRAVPR1ALTB4R2 | |
| SCHEMBL2604 | 0.80 | NLRP3 (0.41) | NLRP3ESR2ALDH1A1FFAR1AKR1B1 | |
| SCHEMBL2686 | 0.79 | ESR2 (0.40) | NLRP3ESR2ALDH1A1FFAR1AKR1B1 | |
| SCHEMBL2405898 | 0.78 | SMN1; SMN2 (0.65) | SMN1; SMN2ALDH1A1MAPTCYP4F2CYP4A11 | |
| SCHEMBL1628 | 0.77 | ESR2 (0.43) | ESR2SMN1; SMN2ALDH1A1FFAR1AKR1B1 | |
| SCHEMBL2103 | 0.76 | MYC (0.47) | NLRP3ESR2SMN1; SMN2ALDH1A1FFAR1 | |
| SCHEMBL2934 | 0.75 | GPR119 (0.43) | ESR2SMN1; SMN2ALDH1A1KDM4EGRIA2 | |
| SCHEMBL7270546 | 0.75 | ESR2 (0.46) | ESR2SMN1; SMN2ALDH1A1FFAR1AKR1B1 | |
| SCHEMBL3058 | 0.73 | OXTR (0.41) | ESR2SMN1; SMN2ALDH1A1FFAR1AKR1B1 | |
| SCHEMBL6555905 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2GAAL3MBTL1MAPTCYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5965592-A | HYPOTENSIVE AGENTS | NOVARTIS CORPORATION (US) | 1999-10-12 | — | — | US | disclosed |
| EP-0443983-B1 | Acyl compounds | CIBA GEIGY AG (CH) | 1996-02-28 | — | — | EP | disclosed |
| US-5399578-A | Hypotensive; valsartan; high blood pressure and cardiac insufficiency | CIBA-GEIGY CORP (US) | 1995-03-21 | — | — | US | disclosed |
| EP-0443983-A1 | Acyl compounds | CIBA-GEIGY AG (CH) | 1991-08-28 | — | — | EP | disclosed |