Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TTR | P02766 | 1/20 | 0.53 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550937 | 0.78 | KMT2A (0.56) | MEN1KMT2AALDH1A1ADRA1DADRA1A | |
| SCHEMBL30740619 | 0.77 | TTR (0.58) | MEN1KMT2AALDH1A1TTRPOLB | |
| SCHEMBL11109442 | 0.75 | HTR1A (0.63) | MEN1KMT2AALDH1A1ADRA1DADRA1A | |
| SCHEMBL2782744 | 0.75 | DRD2 (0.52) | ALDH1A1TTRHTR1ADRD2CYP2C9 | |
| SCHEMBL28081247 | 0.74 | SLC6A3 (0.65) | MEN1KMT2AALDH1A1SIGMAR1KCNH2 | |
| SCHEMBL4527775 | 0.74 | DRD4 (0.57) | KMT2AALDH1A1DRD2SIGMAR1 | |
| SCHEMBL26968308 | 0.74 | TTR (0.57) | ALDH1A1TTRHTR1ADRD2SIGMAR1 | |
| SCHEMBL29835980 | 0.74 | TTR (0.57) | ALDH1A1TTRHTR1ADRD2SIGMAR1 | |
| SCHEMBL2781571 | 0.73 | NPC1 (0.50) | ALDH1A1TTRCYP2C9 | |
| SCHEMBL24170899 | 0.72 | DRD2 (0.57) | HTR1ADRD2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0660832-B1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMA INC (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5436246-A | Compounds for treatment of anxiety, depression, migraine, stroke, angina and hypertension | MERRELL DOW PHARMACEUTICALS INC. | 1995-07-25 | — | — | US | disclosed |
| EP-0660832-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006789-A1 | SEROTONIN RECEPTOR AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-31 | — | — | WO | disclosed |