Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR1F | P30939 | 1/20 | 0.41 |
| ▸ | CCR2 | P41597 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720776 | 0.83 | HRH3 (0.47) | EPHX2TRPV1HRH3NPC1RAB9A | |
| SCHEMBL8550183 | 0.83 | EPHX2 (0.48) | EPHX2TRPV1HRH3NPC1RAB9A | |
| SCHEMBL7483679 | 0.83 | HTR1D (0.62) | HTR1AHTR1DHTR1BHTR1FCCR2 | |
| SCHEMBL8552303 | 0.80 | RAB9A (0.43) | HRH3NPC1RAB9ASMN1; SMN2HTR1A | |
| SCHEMBL8551242 | 0.77 | MEN1 (0.43) | HRH3NPC1RAB9AMEN1KMT2A | |
| SCHEMBL8550760 | 0.76 | MAPT (0.46) | NPC1RAB9ALMNASMN1; SMN2MEN1 | |
| SCHEMBL8547952 | 0.76 | HTR1D (0.45) | HRH3RAB9ASMN1; SMN2HTR1DHTR1B | |
| SCHEMBL8547892 | 0.74 | HTR1D (0.46) | HRH3HTR1DHTR1B | |
| SCHEMBL8548440 | 0.74 | CA2 (0.43) | EPHX2TRPV1MEN1KMT2A | |
| SCHEMBL8551288 | 0.74 | HTR1D (0.40) | HRH3LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |