Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.48 |
| ▸ | DRD2 | P14416 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 3/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7483679 | 0.83 | HTR1D (0.62) | DRD2CCR2HTR1FHTR1AHTR1D | |
| SCHEMBL8551434 | 0.83 | EPHX2 (0.48) | EPHX2TRPV1HRH3NPC1RAB9A | |
| SCHEMBL8704542 | 0.77 | ALDH1A1 (0.53) | EPHX2DRD2HTR2ADRD3NPC1 | |
| SCHEMBL8551986 | 0.77 | HTR1F (0.68) | DRD2HTR2ADRD3HTR1FHTR1A | |
| SCHEMBL8546763 | 0.76 | HTR1D (0.45) | DRD2HTR2ADRD3HTR1DHTR1B | |
| SCHEMBL8551958 | 0.75 | DRD2 (0.57) | DRD2HTR2ADRD3HTR1DHTR1B | |
| SCHEMBL8548237 | 0.74 | MAPT (0.53) | DRD2HTR2ADRD3NPC1RAB9A | |
| SCHEMBL8548755 | 0.74 | CA2 (0.43) | EPHX2DRD2HTR2ADRD3MEN1 | |
| SCHEMBL8548758 | 0.73 | DRD2 (0.40) | DRD2HTR2ADRD3 | |
| SCHEMBL8549413 | 0.72 | ALDH1A1 (0.40) | EPHX2DRD2HTR2ADRD3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |