Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.40 |
| ▸ | HTR1B | P28222 | 9/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547952 | 0.86 | HTR1D (0.45) | HTR1DHTR1BHDAC3HDAC1HDAC6 | |
| SCHEMBL8547892 | 0.85 | HTR1D (0.46) | HTR1DHTR1BHDAC3HDAC1HDAC6 | |
| SCHEMBL8723639 | 0.84 | KDM4E (0.40) | HTR1DHTR1BDRD2SLC6A4HRH3 | |
| SCHEMBL7483686 | 0.82 | HTR1D (0.62) | HTR1DHTR1BDRD2 | |
| SCHEMBL8547896 | 0.80 | DRD2 (0.37) | HTR1DHTR1BDRD2SLC6A4HRH3 | |
| SCHEMBL8552507 | 0.79 | DRD2 (0.39) | HTR1DHTR1BDRD2SLC6A4MEN1 | |
| SCHEMBL8551242 | 0.78 | MEN1 (0.43) | HRH3MEN1MAPTKMT2A | |
| SCHEMBL8547946 | 0.76 | KMT2A (0.41) | DRD2SLC6A4KDM4EMEN1LMNA | |
| SCHEMBL8547528 | 0.76 | UBE2M (0.49) | — | |
| SCHEMBL8552293 | 0.76 | LMNA (0.42) | HTR1DHTR1BDRD2SLC6A4KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |