Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.39 |
| ▸ | ELANE | P08246 | 2/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552639 | 0.88 | EDNRB (0.43) | EDNRBELANEEDNRAALDH1A1MAPT | |
| SCHEMBL8552494 | 0.85 | EDNRB (0.49) | EDNRBELANEEDNRAF2PLAU | |
| SCHEMBL8551818 | 0.85 | EDNRB (0.41) | EDNRBEDNRAALDH1A1MAPT | |
| SCHEMBL8552678 | 0.85 | EDNRB (0.43) | EDNRBEDNRAMAPTNPC1RAB9A | |
| SCHEMBL8547749 | 0.84 | EDNRB (0.41) | EDNRBEDNRAALDH1A1 | |
| SCHEMBL8552487 | 0.84 | EDNRB (0.44) | EDNRBEDNRAMAPT | |
| SCHEMBL8552520 | 0.83 | EDNRB (0.46) | EDNRBELANEEDNRAF2PLAU | |
| SCHEMBL8546118 | 0.83 | EDNRB (0.42) | EDNRBELANEEDNRAMEN1KMT2A | |
| SCHEMBL8548809 | 0.81 | EDNRB (0.54) | EDNRBELANEEDNRAF2PLAU | |
| SCHEMBL8548588 | 0.80 | EDNRB (0.40) | EDNRBEDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |