SCHEMBL8551928

SCHEMBL8551928

CC(O)CC(Oc1ccc(/C=C/c2ccccc2)cc1)c1cccnc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 1/20 0.43
CYP11B2 P19099 1/20 0.43
SMN1; SMN2 Q16637 2/20 0.41
LTB4R Q15722 1/20 0.39
LTB4R2 Q9NPC1 1/20 0.39
PPARG P37231 1/20 0.39
PPARA Q07869 1/20 0.39
TBXAS1 P24557 2/20 0.39
TP53 P04637 2/20 0.39
CYP2D6 P10635 2/20 0.39
HSD17B10 Q99714 2/20 0.39
NPC1 O15118 1/20 0.39
MTOR P42345 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
MAPK1 P28482 1/20 0.39
CYP2C19 P33261 1/20 0.39
KDM4E B2RXH2 3/20 0.38
CHRNA7 P36544 3/20 0.38
HPGD P15428 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8555774 0.89 CYP11B1 (0.42) CYP11B1CYP11B2SMN1; SMN2LTB4RLTB4R2
SCHEMBL8109544 0.86 SMN1; SMN2 (0.44) SMN1; SMN2CYP2D6CYP3A4CYP2C9CYP2C19
SCHEMBL8551523 0.84 CYP17A1 (0.47) SMN1; SMN2HSD17B10CYP3A4HPGDLMNA
SCHEMBL7772046 0.83 SLC6A4 (0.42) SMN1; SMN2CYP3A4HPGDLMNATDP1
SCHEMBL7773934 0.83 SLC6A4 (0.42) SMN1; SMN2CYP3A4HPGDLMNATDP1
SCHEMBL8551073 0.82 MAPK1 (0.47) SMN1; SMN2PPARGPPARAMAPK1CYP2C19
SCHEMBL8552624 0.81 CYP19A1 (0.47) CYP11B1CYP11B2SMN1; SMN2CYP2D6CYP3A4
SCHEMBL8133883 0.80 CYP17A1 (0.40) SMN1; SMN2CYP2D6CYP3A4CYP2C9CYP2C19
SCHEMBL8550969 0.79 EPHX1 (0.46) SMN1; SMN2
SCHEMBL8555652 0.78 PPARG (0.41) CYP11B1CYP11B2SMN1; SMN2PPARGPPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0865431-A2 COMPOUNDS Astra Pharmaceuticals Limited (GB) 1998-09-23 EP disclosed
WO-1997020815-A1 COMPOUNDS ASTRA PHARMACEUTICALS LTD. (GB) 1997-06-12 WO disclosed