Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 2/20 | 0.48 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.48 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.48 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.48 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | PRCP | P42785 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18812549 | 0.94 | OPRM1 (0.46) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL29082026 | 0.82 | GRIN1 (0.47) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| Ammonia Solution, Strong SCHEMBL29082373 | 0.81 | GRIN1 (0.46) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL12488543 | 0.79 | GRIN2D (0.44) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL30338318 | 0.77 | MEN1 (0.47) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL4296257 | 0.76 | OPRM1 (0.44) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL5171384 | 0.74 | OPRL1 (0.46) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL5466007 | 0.73 | ALDH1A1 (0.41) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL6317684 | 0.73 | ALDH1A1 (0.41) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A | |
| SCHEMBL29185211 | 0.73 | HSD11B1 (0.41) | GRIN2DGRIN3BGRIN1KCNH2GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840732-A1 | SUBSTITUTED BENZOLACTAM COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997003066-A1 | SUBSTITUTED BENZOLACTAM COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1997-01-30 | — | — | WO | disclosed |