Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.34 |
| ▸ | HTR1B | P28222 | 9/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552196 | 0.86 | HTR1D (0.34) | HTR1DHTR1BDRD2SLC6A4KEAP1 | |
| SCHEMBL7489257 | 0.83 | HTR1D (0.54) | HTR1DHTR1BDRD2CCR2 | |
| SCHEMBL8548389 | 0.83 | DRD2 (0.39) | HTR1DHTR1BDRD2MTNR1A | |
| SCHEMBL7489260 | 0.83 | HTR1D (0.54) | HTR1DHTR1BDRD2CCR2 | |
| SCHEMBL8709053 | 0.78 | DRD2 (0.33) | DRD2SLC6A4 | |
| SCHEMBL8552203 | 0.78 | CCR2 (0.43) | HTR1DHTR1BDRD2SLC6A4CCR2 | |
| SCHEMBL8547967 | 0.78 | MAPT (0.46) | MAPTKDM4E | |
| SCHEMBL8708863 | 0.77 | UBE2M (0.47) | — | |
| SCHEMBL8550270 | 0.75 | LMNA (0.42) | DRD2SLC6A4CHRM4MAPT | |
| SCHEMBL8704365 | 0.75 | DRD2 (0.42) | HTR1DHTR1BDRD2SLC6A4CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |