Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.41 |
| ▸ | PDE4A | P27815 | 11/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551025 | 0.91 | GAA (0.44) | KDM4EALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL8594175 | 0.84 | ALDH1A1 (0.39) | KDM4EUSP2ALDH1A1MAPTHPGD | |
| SCHEMBL8552291 | 0.84 | CLK1 (0.40) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8549519 | 0.83 | KDM4E (0.38) | PDE4BKDM4EALDH1A1HPGD | |
| SCHEMBL8551848 | 0.81 | CTSV (0.52) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL8549511 | 0.80 | KDM4E (0.40) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL8553124 | 0.78 | GABRA1 (0.43) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL8553319 | 0.77 | PDE4B (0.40) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8546850 | 0.77 | KDM4E (0.52) | KDM4EALDH1A1TP53MAPTHPGD | |
| SCHEMBL8547128 | 0.75 | EDNRB (0.49) | PDE4BPDE4DPDE4APDE4CFFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |