Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.40 |
| ▸ | PDE4A | P27815 | 5/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8591475 | 0.92 | PTPN1 (0.42) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL8553299 | 0.86 | PTPN1 (0.38) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL8550982 | 0.85 | CTSV (0.44) | ALDH1A1MAPTHPGDELANEPTPN1 | |
| SCHEMBL8553723 | 0.78 | FFAR1 (0.44) | KMT2AMEN1ALDH1A1MAPTHPGD | |
| SCHEMBL8552296 | 0.77 | PDE4B (0.42) | PDE4BPDE4DPDE4APDE4CKDM4E | |
| SCHEMBL8549574 | 0.75 | EDNRB (0.43) | PDE4BPDE4DPDE4APDE4CPTGDR2 | |
| SCHEMBL8550648 | 0.74 | EDNRB (0.42) | PDE4BPDE4DPDE4APDE4CPTGDR2 | |
| SCHEMBL8551010 | 0.73 | KDM4E (0.47) | KMT2AMEN1KDM4EALDH1A1MAPT | |
| SCHEMBL8697275 | 0.73 | PTPN1 (0.42) | PTGDR2ALDH1A1MAPTPTPN1 | |
| SCHEMBL8552291 | 0.73 | CLK1 (0.40) | PDE4BPDE4DPDE4APDE4CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |