Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8555665 | 0.99 | MAPT (0.47) | MAPTALDH1A1TP53SIGMAR1LMNA | |
| SCHEMBL8557609 | 0.88 | SIGMAR1 (0.51) | MAPTSIGMAR1L3MBTL1POLB | |
| Hydrochloric Acid SCHEMBL8628369 | 0.77 | HTR2A (0.45) | MAPTALDH1A1LMNAGAA | |
| SCHEMBL2376923 | 0.71 | SIGMAR1 (0.76) | MAPTALDH1A1SIGMAR1LMNATSHR | |
| SCHEMBL8595796 | 0.69 | ALDH1A1 (0.67) | ALDH1A1SIGMAR1TSHRGAA | |
| SCHEMBL16125046 | 0.69 | AGER (0.48) | MAPTALDH1A1SIGMAR1LMNA | |
| SCHEMBL11552775 | 0.67 | ALDH1A1 (0.37) | MAPTALDH1A1LMNATSHRHTT | |
| SCHEMBL6309156 | 0.67 | ALDH1A1 (0.37) | MAPTALDH1A1LMNATSHRHTT | |
| SCHEMBL8595798 | 0.66 | SLC6A2 (0.37) | ALDH1A1SIGMAR1 | |
| SCHEMBL14720872 | 0.65 | ALDH1A1 (0.50) | MAPTALDH1A1LMNAHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0883613-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1998-12-16 | — | — | EP | claimed |
| WO-1997029097-A1 | SULFONAMIDE DERIVATIVES AS 5HT7 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-14 | — | — | WO | claimed |