Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.34 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547929 | 0.84 | MAPK14 (0.36) | RAB9AKCNK3KCNK9MAPK14HSPB1 | |
| SCHEMBL7138889 | 0.83 | HTR1F (0.45) | RAB9AKCNK3KCNK9LRRK2MEN1 | |
| SCHEMBL8548429 | 0.69 | LRRK2 (0.36) | RAB9AKCNK3KCNK9MAPK14HSPB1 | |
| SCHEMBL7145099 | 0.69 | HTR1F (0.51) | RAB9AKCNK3KCNK9MAPK14HSPB1 | |
| SCHEMBL8553318 | 0.64 | MAPT (0.43) | RAB9AMEN1MAPTKMT2AKDM4E | |
| SCHEMBL13546243 | 0.62 | KCNK3 (0.60) | RAB9AKCNK3KCNK9MAPK14HSPB1 | |
| SCHEMBL8546818 | 0.62 | DYRK1A (0.36) | RAB9AEGFRMEN1MAPTKMT2A | |
| SCHEMBL18027799 | 0.60 | RAB9A (0.65) | RAB9AKCNK3KCNK9MEN1MAPT | |
| SCHEMBL7142217 | 0.60 | HTR1F (0.62) | RAB9ALRRK2MEN1MAPTKMT2A | |
| SCHEMBL8288209 | 0.59 | HDAC1 (0.69) | RAB9AKCNK3KCNK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |