Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.35 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.35 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.35 |
| ▸ | HTR1F | P30939 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547929 | 0.85 | MAPK14 (0.36) | LRRK2MAPK14HSPB1RAB9AKCNK3 | |
| SCHEMBL7145099 | 0.85 | HTR1F (0.51) | LRRK2MAPK14HSPB1RAB9AKCNK3 | |
| SCHEMBL8549783 | 0.71 | GRM5 (0.37) | RAB9AHTR1FCA9 | |
| SCHEMBL8549636 | 0.71 | HTR1F (0.51) | RAB9AKCNK3KCNK9HTR1FCA9 | |
| SCHEMBL8548549 | 0.71 | HTR1F (0.50) | MAPK14RAB9AKCNK3KCNK9HTR1F | |
| SCHEMBL8552317 | 0.69 | RAB9A (0.36) | LRRK2MAPK14HSPB1RAB9AKCNK3 | |
| SCHEMBL7138889 | 0.69 | HTR1F (0.45) | LRRK2RAB9AKCNK3KCNK9HTR1F | |
| SCHEMBL8552580 | 0.69 | HTR1F (0.65) | RAB9AKCNK3KCNK9HTR1FSNCA | |
| SCHEMBL8547488 | 0.69 | HTR1F (0.53) | RAB9AKCNK3HTR1FCA9SNCA | |
| SCHEMBL8548295 | 0.68 | RAB9A (0.51) | RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |