Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | KCNA5 | P22460 | 4/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.41 |
| ▸ | CTSA | P10619 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | PTAFR | P25105 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.38 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.38 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554522 | 0.87 | KCNA5 (0.42) | KCNA5CTSLCTSSCTSKFFAR1 | |
| SCHEMBL8550969 | 0.86 | EPHX1 (0.46) | EPHX1KCNA5CTSLCTSSCTSK | |
| SCHEMBL8553452 | 0.85 | SUCNR1 (0.41) | HTTADRB1ADRB3AKR1C3AKR1C2 | |
| SCHEMBL8549826 | 0.84 | KCNA5 (0.43) | KCNA5CTSLCTSSCTSKKCNH2 | |
| SCHEMBL8551344 | 0.84 | CYP19A1 (0.47) | PTAFRSUCNR1 | |
| SCHEMBL8556196 | 0.83 | PDE4D (0.41) | AKR1C3AKR1C2 | |
| SCHEMBL8553713 | 0.82 | CYP17A1 (0.42) | CTSLCTSSCTSKADRB1ADRB3 | |
| SCHEMBL8554677 | 0.77 | EPHX1 (0.42) | EPHX1KCNA5CTSLCTSSCTSK | |
| SCHEMBL2526 | 0.76 | HTT (0.44) | KCNA5HTT | |
| SCHEMBL8118689 | 0.76 | KCNA5 (0.48) | KCNA5DGAT2PTAFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |