Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | LARS1 | Q9P2J5 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | CTSS | P25774 | 1/20 | 0.37 |
| ▸ | CTSK | P43235 | 1/20 | 0.37 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554522 | 0.83 | KCNA5 (0.42) | MAPTPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL8551344 | 0.83 | CYP19A1 (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL8552369 | 0.82 | EPHX1 (0.45) | CTSLCTSSCTSKADRB1ADRB3 | |
| SCHEMBL8549826 | 0.81 | KCNA5 (0.43) | CYP17A1CYP11B1CYP11B2PSEN1PSEN2 | |
| SCHEMBL8556196 | 0.80 | PDE4D (0.41) | MAPTCYP11B1CYP11B2LMNA | |
| SCHEMBL8553452 | 0.74 | SUCNR1 (0.41) | MAPTADRB1ADRB3LMNA | |
| SCHEMBL7966525 | 0.73 | PTAFR (0.44) | CYP17A1CYP3A4LARS1MAPTCYP11B1 | |
| SCHEMBL7966529 | 0.73 | PTAFR (0.44) | CYP17A1CYP3A4LARS1MAPTCYP11B1 | |
| SCHEMBL8481898 | 0.73 | ADAMTS4 (0.44) | CYP17A1CYP3A4MAPTCYP11B1CYP11B2 | |
| SCHEMBL8118375 | 0.73 | KCNA5 (0.49) | CYP3A4MAPTADRB1ADRB3MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |