Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 6/20 | 0.51 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 6/20 | 0.43 |
| ▸ | HTR1B | P28222 | 6/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8590783 | 0.88 | DRD2 (0.46) | RORCDRD2SLC6A4HTR1DHTR1B | |
| SCHEMBL8552391 | 0.85 | RORC (0.49) | RORCDCUN1D1HTR1BL3MBTL1ACKR3 | |
| SCHEMBL8552432 | 0.84 | RORC (0.51) | RORCDCUN1D1DRD2SLC6A4HTR1D | |
| SCHEMBL7483539 | 0.84 | RORC (0.69) | RORCDRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8550766 | 0.84 | HTR1D (0.50) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8548938 | 0.83 | HTR1D (0.63) | DRD2SLC6A4HTR1DHTR1BCHRM2 | |
| SCHEMBL8549540 | 0.83 | HTR1D (0.48) | DRD2SLC6A4HTR1DHTR1BCHRM2 | |
| SCHEMBL8548076 | 0.82 | DRD2 (0.47) | RORCDCUN1D1DRD2SLC6A4HTR1D | |
| SCHEMBL8547499 | 0.82 | HTR1D (0.46) | DRD2SLC6A4HTR1DHTR1BCHRM2 | |
| SCHEMBL8548023 | 0.82 | DRD2 (0.50) | DCUN1D1DRD2SLC6A4HTR1DHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |