Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11658266 | 0.85 | CA2 (0.41) | — | |
| SCHEMBL8552891 | 0.80 | HTR1A (0.38) | ACHE | |
| SCHEMBL11663139 | 0.79 | L3MBTL1 (0.39) | L3MBTL1 | |
| SCHEMBL11657344 | 0.73 | LMNA (0.52) | L3MBTL1 | |
| SCHEMBL6207136 | 0.73 | PTGS2 (0.36) | PTGS1PTGS2 | |
| SCHEMBL6205230 | 0.72 | PTGS2 (0.44) | L3MBTL1PTGS1PTGS2 | |
| SCHEMBL6205723 | 0.72 | PNMT (0.40) | PTGS1PTGS2ACHE | |
| SCHEMBL11563863 | 0.71 | TSHR (0.39) | — | |
| SCHEMBL11656836 | 0.71 | ACHE (0.48) | L3MBTL1ACHE | |
| SCHEMBL11663467 | 0.71 | ACHE (0.47) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098891-B1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA GMBH (DE) | 2005-08-10 | — | — | EP | disclosed |
| EP-1157015-B1 | USE OF POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS FOR THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF LIPOMETABOLIC DISORDERS, OBESITAS AND TYP II DIABETES | AVENTIS PHARMA GMBH (DE) | 2005-05-11 | — | — | EP | disclosed |
| EP-1173176-B1 | UTILIZATION OF POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS IN THE PRODUCTION OF MEDICAMENTS FOR PROPHYLAXIS OR TREATMENT OF OBESITY | AVENTIS PHARMA GMBH (DE) | 2004-05-26 | — | — | EP | disclosed |
| US-6476059-B1 | Use of polycyclic 2-aminothiazole systems for the treatment of obesity | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-11-05 | — | — | US | disclosed |
| EP-1173176-A1 | UTILIZATION OF POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS IN THE PRODUCTION OF MEDICAMENTS FOR PROPHYLAXIS OR TREATMENT OF OBESITY | Aventis Pharma Deutschland GmbH (DE) | 2002-01-23 | — | — | EP | disclosed |
| EP-1157015-A1 | POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING SAID COMPOUNDS | Aventis Pharma Deutschland GmbH (DE) | 2001-11-28 | — | — | EP | disclosed |
| US-6251922-B1 | TREATMENT OF OBESITY AND DIABETES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2001-06-26 | — | — | US | disclosed |
| EP-1098891-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | Aventis Pharma Deutschland GmbH (DE) | 2001-05-16 | — | — | EP | disclosed |
| US-6159996-A | Polycyclic thiazolidin-2-ylidene amines, process for their preparation, and their use as pharmaceuticals | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-12-12 | — | — | US | disclosed |
| WO-2000051602-A1 | UTILIZATION OF POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS IN THE PRODUCTION OF MEDICAMENTS FOR PROPHYLAXIS OR TREATMENT OF OBESITY | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000051995-A1 | POLYCYCLIC 2-AMINO-THIAZOLE SYSTEMS, METHOD FOR THE PRODUCTION THEREOF AND MEDICAMENT CONTAINING SAID COMPOUNDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000004006-A1 | POLYCYCLIC THIAZOLIDIN-2-YLIDENE AMINES, METHOD FOR THE PRODUCTION AND USE THEREOF AS MEDICAMENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-01-27 | — | — | WO | disclosed |