Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | APEX1 | P27695 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555961 | 0.93 | HTR1A (0.68) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8554060 | 0.89 | KDM4E (0.63) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9582012 | 0.84 | TDP1 (0.80) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8553783 | 0.83 | HTR1A (0.81) | HTR1ADRD2 | |
| SCHEMBL8871477 | 0.82 | HTR1A (0.63) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8555542 | 0.82 | TDP1 (0.71) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8558887 | 0.81 | HTR1A (0.73) | TDP1HTR1ADRD2CYP1A2CYP3A4 | |
| SCHEMBL8555410 | 0.80 | HTR1A (0.52) | HTR1ADRD2 | |
| SCHEMBL8554084 | 0.79 | HTR1A (0.78) | HTR1ADRD2DRD3 | |
| SCHEMBL9581509 | 0.78 | TDP1 (0.79) | TDP1KDM4EALOX15APEX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |