Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | HTR1D | P28221 | 1/20 | 0.55 |
| ▸ | HTR1B | P28222 | 1/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553115 | 0.93 | TDP1 (0.59) | HTR1AKDM4EALOX15APEX1KMT2A | |
| SCHEMBL8554060 | 0.91 | KDM4E (0.63) | HTR1AKDM4EALOX15APEX1KMT2A | |
| SCHEMBL8553783 | 0.91 | HTR1A (0.81) | HTR1ADRD2SLC6A4 | |
| SCHEMBL8871477 | 0.89 | HTR1A (0.63) | HTR1AKDM4EALOX15APEX1KMT2A | |
| SCHEMBL8558887 | 0.88 | HTR1A (0.73) | HTR1ATDP1DRD2SLC6A4 | |
| SCHEMBL9582012 | 0.86 | TDP1 (0.80) | HTR1AKDM4EALOX15APEX1KMT2A | |
| SCHEMBL8554084 | 0.86 | HTR1A (0.78) | HTR1ADRD2 | |
| SCHEMBL8555542 | 0.84 | TDP1 (0.71) | HTR1AKDM4EALOX15APEX1KMT2A | |
| SCHEMBL8553977 | 0.84 | HTR1A (0.70) | HTR1ADRD2SLC6A4 | |
| SCHEMBL9581509 | 0.83 | TDP1 (0.79) | HTR1AKDM4EALOX15APEX1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |