Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 5/20 | 0.49 |
| ▸ | HTR1B | P28222 | 4/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556808 | 0.98 | HTR1A (0.52) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8553791 | 0.93 | HTR1A (0.59) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871803 | 0.93 | HTR1A (0.58) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8554898 | 0.90 | HTR1A (0.63) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8871079 | 0.90 | HTR1A (0.63) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8870158 | 0.90 | HTR7 (0.55) | HTR1ADRD2HTR7HTR1DHTR1B | |
| SCHEMBL8557556 | 0.89 | HTR1A (0.64) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL27431034 | 0.89 | HTR1A (0.57) | HTR1ADRD2HTR7HTR1DHTR1B | |
| SCHEMBL8553950 | 0.88 | ADRA2A (0.61) | HTR1AADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8555534 | 0.88 | HTR1A (0.59) | HTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |