Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.39 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551198 | 0.84 | CYP3A4 (0.52) | PDE4DCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8550178 | 0.83 | PDE4D (0.42) | PDE4DAKR1C3AKR1C2CYP19A1CYP11B1 | |
| SCHEMBL8555025 | 0.82 | PDE4D (0.52) | PDE4DFFAR1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL8313802 | 0.81 | FFAR1 (0.53) | PDE4DFFAR1 | |
| SCHEMBL8319920 | 0.79 | PDE4D (0.48) | PDE4DFFAR1RAB9A | |
| SCHEMBL27539172 | 0.78 | SLC6A2 (0.52) | PDE4DCYP19A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8553432 | 0.72 | CYP17A1 (0.55) | PDE4DFFAR1CYP19A1 | |
| SCHEMBL8317319 | 0.72 | KCNA5 (0.40) | PDE4DFFAR1CYP19A1CYP3A4CYP2D6 | |
| SCHEMBL8318114 | 0.71 | SMN1; SMN2 (0.57) | CYP3A4CYP2D6SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL9312935 | 0.71 | PDE4D (0.40) | PDE4DFFAR1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |