Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 3/20 | 0.40 |
| ▸ | ITGAV | P06756 | 3/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551198 | 0.90 | CYP3A4 (0.52) | PDE4DCYP3A4CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8553432 | 0.85 | CYP17A1 (0.55) | PDE4DCYP19A1CYP17A1ITGB3ITGAV | |
| SCHEMBL27539172 | 0.83 | SLC6A2 (0.52) | PDE4DCYP19A1CYP11B1CYP11B2CYP3A4 | |
| SCHEMBL8553222 | 0.82 | PDE4D (0.49) | PDE4DCYP19A1CYP11B1CYP11B2CYP3A4 | |
| Hydrochloric Acid SCHEMBL8555644 | 0.80 | CYP3A4 (0.44) | PDE4DCYP2C9HSD17B10CYP19A1CYP11B1 | |
| SCHEMBL8552254 | 0.74 | SUCNR1 (0.50) | PDE4DCYP17A1ITGB3ITGAVITGA2B | |
| SCHEMBL9519691 | 0.73 | L3MBTL1 (0.50) | PDE4DITGB3ITGAVITGA2BTBXAS1 | |
| SCHEMBL3413768 | 0.68 | LMNA (0.55) | CYP2D6FFAR1LMNAHPGD | |
| SCHEMBL2303019 | 0.68 | CCNC (0.48) | PDE4DCYP3A4TBXAS1CTSALMNA | |
| SCHEMBL17591689 | 0.68 | LMNA (0.54) | PDE4DSLC6A2SLC6A4SLC6A3TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865431-A2 | COMPOUNDS | Astra Pharmaceuticals Limited (GB) | 1998-09-23 | — | — | EP | disclosed |
| WO-1997020815-A1 | COMPOUNDS | ASTRA PHARMACEUTICALS LTD. (GB) | 1997-06-12 | — | — | WO | disclosed |