Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | GLS | O94925 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552715 | 0.84 | LMNA (0.47) | LMNAGAAKDM4EFAAHALDH1A1 | |
| SCHEMBL8552717 | 0.84 | LMNA (0.47) | LMNAGAAKDM4EFAAHALDH1A1 | |
| SCHEMBL8553074 | 0.83 | L3MBTL1 (0.45) | LMNAGLSL3MBTL1POLBEPHX1 | |
| SCHEMBL8554046 | 0.82 | LMNA (0.42) | LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL8554049 | 0.82 | LMNA (0.42) | LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL1899913 | 0.76 | LMNA (0.53) | LMNAGAAL3MBTL1POLBEPHX1 | |
| SCHEMBL8549891 | 0.73 | L3MBTL1 (0.41) | GLSL3MBTL1POLBEPHX1KDM4E | |
| SCHEMBL8549754 | 0.73 | SMYD3 (0.45) | L3MBTL1POLBEPHX1KDM4EPKM | |
| Hydrochloric Acid SCHEMBL8627559 | 0.72 | LMNA (0.43) | LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL8626111 | 0.71 | GLS (0.41) | GLSKDM4EPKMMAPTFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |