Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 7/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554046 | 1.00 | LMNA (0.42) | LMNAGAACHRM4CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL8549999 | 0.99 | LMNA (0.41) | LMNAGAACHRM4CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL8627559 | 0.89 | LMNA (0.43) | LMNAGAACHRM4CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL8551751 | 0.89 | LMNA (0.43) | LMNAGAACHRM4CHRM2CHRM1 | |
| SCHEMBL8553358 | 0.82 | LMNA (0.44) | LMNAGAAKDM4EALDH1A1 | |
| SCHEMBL8550439 | 0.81 | ITGB3 (0.38) | ITGB3ITGA2BHPGDS | |
| SCHEMBL8550434 | 0.81 | ITGB3 (0.38) | ITGB3ITGA2BHPGDS | |
| SCHEMBL8552715 | 0.78 | LMNA (0.47) | LMNAGAACHRM4KDM4EALDH1A1 | |
| SCHEMBL8552717 | 0.78 | LMNA (0.47) | LMNAGAACHRM4KDM4EALDH1A1 | |
| SCHEMBL8628646 | 0.73 | IKBKB (0.34) | ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |